CRISPR-Cas Conference
Control and Access: Intellectual property and CRISPR-Cas gene editing for innovation in crop agriculture
October 24-25, 2019 Keystone Policy Center and Keystone Lodge Keystone, Colorado, USA
Organized by Colorado State University, with support from: Program on Social Implications of Food and Agricultural Technologies National Institutes of Food and Agriculture (NIFA), United States Department of Agriculture (USDA) Programme on Biological Resources in Agriculture Co-operative Research Programme (CRP) of the Organisation for Economic Co-operation and Development (OECD)
Conference Objectives
- to provide understanding of the complex and evolving IP landscape, including the licensing arrangements, that governs access to CRISPR for use in commercial crop agriculture
- to compile a range of expert opinion and critical analyses of the current IP situation, as well as perceptions, concerns, and feedback from stakeholders across industry, governments, and NGOs
- to explore implications of the IP and licensing regime on public perceptions, regulatory politics, and, by extension, the incentives and risks of using CRISPR across a wide range of innovations for sustainable agriculture
Background
In 2012 scientific breakthroughs turned a molecular defense mechanism in bacteria called CRISPR-Cas it into a powerful tool for making changes or “edits” to the DNA sequences of any living organisms. It works in microbes, animals, and plants, and promises to be useful for a wide range of applications ranging from human health to improvements in crops. These breakthroughs led to a scramble by universities and companies to secure patents on different aspects of the technology. Then came several years of high profile patent disputes and the weaving of a complex web of licensing deals amongst venture-capital funded startups and large corporations. In the meantime, scientists in academic laboratories around the world were quickly adopting CRISPR gene editing tools for work in their laboratories, thanks to free dissemination for academic research use, via a nonprofit organization called AddGene. The world seems poised for further eruptions of legal conflict as new gene-edited advances are beginning to emerge from the lab and start moving toward commercial application. Yet, against this backdrop, in late 2017 an agreement was announced between Pioneer-DuPont (now Corteva AgSciences) and the Broad Institute, holders of the two largest CRISPR patent portfolios. They are offering non-exclusive licenses for commercial use of the full suite of foundational CRISPR patents in crop agriculture. In the past, proprietary control over research tools—such as those used to create GMO crops—come to be associated with lack of transparency, a general loss of “social license” to use that technology and increased political pressure for regulatory scrutiny. Will things play out differently for the use of CRISPR gene editing in crop agriculture? If so, might the CRISPR licensing framework in agriculture become a model for other industries or technologies?
Conference Registration
Conference Hotel and Travel Information
Airport: Keystone is a quick 90-minute drive from Denver International Airport (DIA) and approximately 70 miles from downtown Denver.
Hotel: The hotel for the conference is the Keystone Lodge and Spa, 22101 US-6, Dillon, CO 80435, a property of Keystone Resort which is owned and operated by Vail Resorts. A block of rooms is being held until September 25, and conference participants can book online with the following link: CSU- CRISPR Intellectual Property Workshop – CP8CRID. (For government rate, use link: CSU- CRISPR Intellectual Property Workshop – CP8CRGT – Government)
Ground transportation: Epic Mountain Express provides shuttle service on a frequent schedule to and from the airport and will take you directly to your accommodations in Keystone in a comfortable and timely fashion. Services offered include both shared-ride shuttles and Private Vehicles. Conference participants are particularly encouraged to utilize these professional services in the event of poor weather conditions.
For car rentals, Hertz is proud to partner with Vail Resorts to offer discounted rates to all guests of Keystone Resort and Conference Center. Conference attendees can take advantage of these discounts through Keystone Reservations.
Local shuttle transportation is available to all Keystone guests from the many bus stops within the resort. Keystone’s free in-resort transportation offers a convenient schedule that will take you to and from your lodging locations to the mountain base areas and Village, conference center, and activities and dining outlets.
Conference venue: The main conference sessions will be held at the Keystone Policy Center, 1628 Saints John Rd, Keystone, CO 80435. The Keystone Policy Center is an easy 10-minute walk from the hotel. (NOTE: There is a convenient underpass for you to cross under U.S. Highway 6.) A local shuttle will also be arranged to depart from the main hotel entrance.
Conference Program
Thursday Oct 24 | |
Introductions | |
University Research in CRISPR and Gene Editing | David Paterson, Assistant Vice President for Research Translation and Commercialization, Colorado State University |
The main objectives of this conference | Gregory Graff, Agricultural and Resource Economics, Colorado State University |
Introduction and View from the OECD Cooperative Research Programme | David Winickoff, OECD |
Session 1. Setting the stage | |
A scientist’s view of the cascading nature of the foundational CRISPR inventions | Stephan Pearce, Soil and Crop Sciences, Colorado State University |
The complexity of the CRISPR patent and licensing landscape | Jake Sherkow, Harvard University and New York Law School |
Session 2. Licensing CRISPR for use in research and commercial innovation | |
Addgene: A Unique Nonprofit Accelerating Science | Joanne Kamens, Executive Director, Addgene |
From the academic side: The licensing principles of the Broad Institute and the development of the joint framework for the nonexclusive licenses to CRISPR-Cas9 for commercial agricultural R&D | Crystal Mao, Director of Strategic Transactions, The Broad Institute of MIT and Harvard University |
From the corporate side: The development of Corteva's CRISPR portfolio and Open Innovation initiative | Matthias Müller, Director of Open Innovation, Corteva Agriscience |
Lunch panel discussion: Agricultural research and commercial innovation utilizing CRISPR | Stephan Pearce, Colorado State University, Matthias Müller, Corteva Agriscience, Cassie Edgar, McKee, Vorhees & Sease, Moderator: Gregory Graff, Colorado State University |
Session 3. Lessons from licensing of other research tools and standard-essential patents | |
How access arrangements constructed around previous biological research tools have affected follow-on research and commercialization | Tania Bubela, Dean, Faculty of Health Sciences, Simon Fraser University |
Is Fair, Reasonable, and Non-Discriminatory (FRAND) licensing applicable to biological research tools? | Bo Heiden, Sahlgrenska School of Innovation and Entrepreneurship, Sahlgrenska School of Medicine, University of Gothenburg and Hoover Institute, Stanford University |
The power of sharing to promote public trust: implications for the case of genome editing technologies | Diane Nicol, Faculty of Law, University of Tasmania |
The political economy of biotechnology | David Zilberman, Robinson Chair Professor of Agricultural and Resource Economics, University of California Berkeley |
Keynote | |
The CRISPR patents: Restoring or damning the fallen angels of Bayh-Dole? | Robert Cook-Deegan, Arizona State University |
Friday October 25 | |
Session 4. Major factors shaping the use of genome editing in agriculture and food | |
The status of regulatory regimes in the US and abroad for use of CRISPR in crops | Fan Li Chou, USDA Biotechnology Adviser |
Factors influencing the use of genome editing in agriculture, food, and bioenergy industries in Europe | Justus Wesseler, Wageningen University |
The range of factors influencing the use of genome editing in agriculture, food, and bioenergy industries in Japan | Yoshiyuki Fujishima, D. Phil., New Energy and Industrial Technology Development Organization (NEDO), Japan |
Session 5. How the degree of IP transparency and access can influence public trust and the politics of new technologies | |
The IP-Regulatory Complex for CRISPR-Cas: Considering Regimes Governing Plant Genetic Resources | Emily Marden, J.D., Faculty of Law, University of British Columbia |
Using the Lens.org as a public and global platform for evidence based mapping of innovation domains: The case of CRISPR-Cas9 | Osmat Jefferson, Science and Engineering Faculty, Queensland University of Technology |
How Intellectual Property Control and Access Influence Stakeholders’ Views on CRISPR use in Agriculture and Food | Carmen Bain, Department of Sociology, Iowa State University |
Keynote | |
CRISPR-Cas9–The complex pathway to a fundamental discovery and what it means for policies | Dominique Guellec, Observatoire des Sciences et Techniques, Paris |
Concluding Session | |
Policy ePanel: Possible futures, big questions, and implications for scientists, policymakers, and the public | Fan Li Chou, USDA, Gregory Graff, Colorado State University, Carmen Bain, Iowa State University, Matthias Müller, Corteva Agriscience, Moderator: Julie Shapiro, Keystone Policy Center |
to be produced and broadcast as a global webinar by Virtual Keystone Symposium |
Sponsored by
United States Department of Agriculture (USDA)
National Institute of Food and Agriculture (NIFA)
Program on Social Implications of Food and Agricultural Technologies
Organized by

Conference advisory board members
Dr. Rafael Blasco, INIA, Ministry of Science and Innovation, Spain, and member of Scientific Advisory Board, Co-operative Research Programme (CRP) Biological Resource Management for Sustainable Agricultural Systems, Trade and Agriculture Directorate, Organisation for Economic Co-operation and Development (OECD)
Julie Shapiro, Senior Policy Director, Keystone Policy Center
Dr. Robert Cook-Deegan, MD, Professor, School for the Future of Innovation in Society, Arizona State University
Jacob Sherkow, JD, Professor of Law, Innovation Center for Law and Technology, New York Law School
Dr. David Winickoff, Secretary, Working Party on Bio-, Nano- and Converging Technologies (BNCT), Directorate for Science, Technology and Innovation, OECD
For more information, please contact
Dr. Gregory D. Graff
Professor, Economics of Innovation and Entrepreneurship
Department of Agricultural & Resource Economics
College of Agricultural Sciences
Colorado State University
Gregory.Graff@colostate.edu
+1-970-491-4028